Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism
Identifieur interne : 001731 ( Main/Exploration ); précédent : 001730; suivant : 001732Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism
Auteurs : Yilong Ma [États-Unis] ; Shichun Peng [États-Unis] ; Phoebe G. Spetsieris [États-Unis] ; Vesna Sossi [Canada] ; David Eidelberg [États-Unis] ; Doris J. Doudet [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2011.
Abstract
Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (
Url:
DOI: 10.1038/jcbfm.2011.166
PubMed: 22126913
PubMed Central: 3318142
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000007
- to stream Pmc, to step Curation: 000007
- to stream Pmc, to step Checkpoint: 000989
- to stream Ncbi, to step Merge: 001015
- to stream Ncbi, to step Curation: 001015
- to stream Ncbi, to step Checkpoint: 001015
- to stream Main, to step Merge: 001804
- to stream Main, to step Curation: 001731
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism</title>
<author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peng, Shichun" sort="Peng, Shichun" uniqKey="Peng S" first="Shichun" last="Peng">Shichun Peng</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spetsieris, Phoebe G" sort="Spetsieris, Phoebe G" uniqKey="Spetsieris P" first="Phoebe G" last="Spetsieris">Phoebe G. Spetsieris</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Physics and Astronomy, University of British Columbia</institution>
, Vancouver, British Columbia,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris J" last="Doudet">Doris J. Doudet</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, University of British Columbia</institution>
, Vancouver, British Columbia,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22126913</idno>
<idno type="pmc">3318142</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318142</idno>
<idno type="RBID">PMC:3318142</idno>
<idno type="doi">10.1038/jcbfm.2011.166</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000007</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000007</idno>
<idno type="wicri:Area/Pmc/Curation">000007</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000007</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000989</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000989</idno>
<idno type="wicri:Area/Ncbi/Merge">001015</idno>
<idno type="wicri:Area/Ncbi/Curation">001015</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001015</idno>
<idno type="wicri:doubleKey">0271-678X:2011:Ma Y:abnormal:metabolic:brain</idno>
<idno type="wicri:Area/Main/Merge">001804</idno>
<idno type="wicri:Area/Main/Curation">001731</idno>
<idno type="wicri:Area/Main/Exploration">001731</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism</title>
<author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peng, Shichun" sort="Peng, Shichun" uniqKey="Peng S" first="Shichun" last="Peng">Shichun Peng</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Spetsieris, Phoebe G" sort="Spetsieris, Phoebe G" uniqKey="Spetsieris P" first="Phoebe G" last="Spetsieris">Phoebe G. Spetsieris</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Physics and Astronomy, University of British Columbia</institution>
, Vancouver, British Columbia,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Center for Neurosciences, The Feinstein Institute for Medical Research</institution>
, Manhasset, New York,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris J" last="Doudet">Doris J. Doudet</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Neurology, University of British Columbia</institution>
, Vancouver, British Columbia,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title>
<idno type="ISSN">0271-678X</idno>
<idno type="eISSN">1559-7016</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [<sup>18</sup>
F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (<italic>P</italic>
<0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights (<italic>r</italic>
>0.88; <italic>P</italic>
<0.0001) and subject scores (<italic>r</italic>
>0.74; <italic>P</italic>
<0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings (<italic>r</italic>
>0.71; <italic>P</italic>
<0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
</noRegion>
<name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<name sortKey="Peng, Shichun" sort="Peng, Shichun" uniqKey="Peng S" first="Shichun" last="Peng">Shichun Peng</name>
<name sortKey="Spetsieris, Phoebe G" sort="Spetsieris, Phoebe G" uniqKey="Spetsieris P" first="Phoebe G" last="Spetsieris">Phoebe G. Spetsieris</name>
</country>
<country name="Canada"><noRegion><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name>
</noRegion>
<name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris J" last="Doudet">Doris J. Doudet</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001731 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001731 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3318142 |texte= Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22126913" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |